A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

• Main Authors: Anh Tuan Nguyen (Author), Alexander Emelyanov (Author), Chor Hui Vivien Koh (Author), Jan M. Spitsbergen (Author), Siew Hong Lam (Author), Sinnakaruppan Mathavan (Author), Serguei Parinov (Author), Zhiyuan Gong (Author)
• Format: Book
• Published: The Company of Biologists, 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein i...