Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking

• Váldodahkkit: Daisuke Ono (Dahkki), Ken Asada (Dahkki), Daishi Yui (Dahkki), Fumika Sakaue (Dahkki), Kotaro Yoshioka (Dahkki), Tetsuya Nagata (Dahkki), Takanori Yokota (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2021-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

DNA/RNA heteroduplex oligonucleotide (HDO), composed of DNA/locked nucleic acid (LNA) antisense oligonucleotide (ASO) and complementary RNA, is a next-generation antisense therapeutic agent. HDO is superior to the parental ASO in delivering to target tissues, and it exerts a more potent gene-silenci...