Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells

• Main Authors: Olga A. Krasheninina (Author), Evgeny K. Apartsin (Author), Elena Fuentes (Author), Aleksandra Szulc (Author), Maksim Ionov (Author), Alya G. Venyaminova (Author), Dzmitry Shcharbin (Author), F. Javier de la Mata (Author), Maria Bryszewska (Author), Rafael Gόmez (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by the evolution of their properties has been observed...