Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone.

• Main Authors: Chong Wang (Author), Linding Xie (Author), Yien Xing (Author), Min Liu (Author), Jun Yang (Author), Nannan Gao (Author), Yihong Cai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Iron is a trace metal element that is essential for the survival of cells and parasites. The role of iron in cerebral toxoplasmosis (CT) is still unclear. Deferiprone (DFP) is the orally active iron chelator that binds iron in a molar ratio of 3:1 (ligand:iron) and promotes urinary iron excretion to...