Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

• Main Authors: Lin Jia (Author), Xiuli Chang (Author), Shuwen Qian (Author), Chen Liu (Author), Caleb C. Lord (Author), Newaz Ahmed (Author), Charlotte E. Lee (Author), Syann Lee (Author), Laurent Gautron (Author), Mack C. Mitchell (Author), Jay D. Horton (Author), Philipp E. Scherer (Author), Joel K. Elmquist (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recent studies have suggested a critical role for toll-like receptor 4 (TLR4) in the development of alcoholic liver disease. As TLR4 is widely expressed throughout the body, it is unclear which TLR4-expressing cell types contribute to alcohol-induced liver damage. Methods: We selectively...