In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

• Main Authors: Jana Janockova (Author), Jan Korabecny (Author), Jana Plsikova (Author), Katerina Babkova (Author), Eva Konkolova (Author), Dana Kucerova (Author), Jana Vargova (Author), Jan Koval (Author), Rastislav Jendzelovsky (Author), Peter Fedorocko (Author), Jana Kasparkova (Author), Viktor Brabec (Author), Jan Rosocha (Author), Ondrej Soukup (Author), Slavka Hamulakova (Author), Kamil Kuca (Author), Maria Kozurkova (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12-17 and urea heterodimers 18-22, and to measure interference with type I and II topoisomerases. Their biological profile was also inspec...