Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis

• Main Authors: Haruna Sawaki (Author), Fumio Nakamura (Author), Michiko Aihara (Author), Yoji Nagashima (Author), Junko Komori-Yamaguchi (Author), Naoya Yamashita (Author), Masatoshi Nakazawa (Author), Yoshio Goshima (Author), Zenro Ikezawa (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Sneezing and persistent itching of the nasal mucosa are distressing symptoms of allergic rhinitis (AR). Recent studies have revealed that hyperinnervation of sensory neurons in the nasal turbinate is one of the underlying causes of sneezing and itching. Since Semaphorin-3A (Sema3A) has be...