Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

• Päätekijät: Anne-Sophie Gautron (Tekijä), Alexandre Juillerat (Tekijä), Valérie Guyot (Tekijä), Jean-Marie Filhol (Tekijä), Emilie Dessez (Tekijä), Aymeric Duclert (Tekijä), Philippe Duchateau (Tekijä), Laurent Poirot (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2017-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of "off-the-shelf" CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking advantage of a previously described strate...