Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

• Hoofdauteurs: Anne-Sophie Gautron (Auteur), Alexandre Juillerat (Auteur), Valérie Guyot (Auteur), Jean-Marie Filhol (Auteur), Emilie Dessez (Auteur), Aymeric Duclert (Auteur), Philippe Duchateau (Auteur), Laurent Poirot (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2017-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of "off-the-shelf" CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking advantage of a previously described strate...