Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

• Asıl Yazarlar: Anne-Sophie Gautron (Yazar), Alexandre Juillerat (Yazar), Valérie Guyot (Yazar), Jean-Marie Filhol (Yazar), Emilie Dessez (Yazar), Aymeric Duclert (Yazar), Philippe Duchateau (Yazar), Laurent Poirot (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2017-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of "off-the-shelf" CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking advantage of a previously described strate...