Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of "off-the-shelf" CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking advantage of a previously described strate...

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Main Authors: Anne-Sophie Gautron (Author), Alexandre Juillerat (Author), Valérie Guyot (Author), Jean-Marie Filhol (Author), Emilie Dessez (Author), Aymeric Duclert (Author), Philippe Duchateau (Author), Laurent Poirot (Author)
Format: Book
Published: Elsevier, 2017-12-01T00:00:00Z.
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3rd Floor Main Library

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