Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug-drug interaction prediction

• Main Authors: Jaidip Gill (Author), Marie Moullet (Author), Anton Martinsson (Author), Filip Miljković (Author), Beth Williamson (Author), Rosalinda H. Arends (Author), Venkatesh Pilla Reddy (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The gold‐standard approach for modeling pharmacokinetic mediated drug-drug interactions is the use of physiologically‐based pharmacokinetic modeling and population pharmacokinetics. However, these models require extensive amounts of drug‐specific data generated from a wide variety of in vit...