Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug-drug interaction prediction

• Główni autorzy: Jaidip Gill (Autor), Marie Moullet (Autor), Anton Martinsson (Autor), Filip Miljković (Autor), Beth Williamson (Autor), Rosalinda H. Arends (Autor), Venkatesh Pilla Reddy (Autor)
• Format: Książka
• Wydane: Wiley, 2022-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract The gold‐standard approach for modeling pharmacokinetic mediated drug-drug interactions is the use of physiologically‐based pharmacokinetic modeling and population pharmacokinetics. However, these models require extensive amounts of drug‐specific data generated from a wide variety of in vit...