T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

• Main Authors: Yáiza Núñez (Author), Annabel Garcia-León (Author), Aïda Falgàs (Author), Naroa Serna (Author), Laura Sánchez-García (Author), Ana Garrido (Author), Jorge Sierra (Author), Alberto Gallardo (Author), Ugutz Unzueta (Author), Esther Vázquez (Author), Antonio Villaverde (Author), Ramon Mangues (Author), Isolda Casanova (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to develop novel therapies that improve treatment effectiveness and overcome drug resistance. We developed T22-PE24-H6, a protein nanoparticle tha...