Pharmacodynamics of Flucloxacillin in a Neutropenic Murine Thigh Infection Model: A Piece of the Puzzle towards Evidence-Based Dosing

• Main Authors: Eveline E. Roelofsen (Author), Brenda C. M. de Winter (Author), Heleen van der Spek (Author), Susan Snijders (Author), Birgit C. P. Koch (Author), Sanne van den Berg (Author), Anouk E. Muller (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For decades, flucloxacillin has been used to treat methicillin-susceptible <i>Staphylococcus aureus</i> (MSSA). Little is still known about its pharmacodynamics (PD). The present study aimed to determine the pharmacokinetic (PK)/PD index and the PD-index value minimally required for effi...