Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

• Main Authors: Céline Cruciani-Guglielmacci (Author), Lara Bellini (Author), Jessica Denom (Author), Masaya Oshima (Author), Neïké Fernandez (Author), Priscilla Normandie-Levi (Author), Xavier P. Berney (Author), Nadim Kassis (Author), Claude Rouch (Author), Julien Dairou (Author), Tracy Gorman (Author), David M. Smith (Author), Anna Marley (Author), Robin Liechti (Author), Dmitry Kuznetsov (Author), Leonore Wigger (Author), Frédéric Burdet (Author), Anne-Laure Lefèvre (Author), Isabelle Wehrle (Author), Ingo Uphues (Author), Tobias Hildebrandt (Author), Werner Rust (Author), Catherine Bernard (Author), Alain Ktorza (Author), Guy A. Rutter (Author), Raphael Scharfmann (Author), Ioannis Xenarios (Author), Hervé Le Stunff (Author), Bernard Thorens (Author), Christophe Magnan (Author), Mark Ibberson (Author)
• Format: Book
• Published: Elsevier, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell dysfunction by analyzing multiple mouse strains in parallel under metabolic...