Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis

• Main Authors: Piotr Soczewka (Author), Damian Kolakowski (Author), Iwona Smaczynska-de Rooij (Author), Weronika Rzepnikowska (Author), Kathryn R. Ayscough (Author), Joanna Kaminska (Author), Teresa Zoladek (Author)
• Format: Book
• Published: The Company of Biologists, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chorea-acanthocytosis (ChAc) is a rare neurodegenerative disease associated with mutations in the human VPS13A gene. The mechanism of ChAc pathogenesis is unclear. A simple yeast model was used to investigate the function of the single yeast VSP13 orthologue, Vps13. Vps13, like human VPS13A, is invo...