Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

• Main Authors: Zhengwei Huang (Author), Han Wu (Author), Beibei Yang (Author), Longkai Chen (Author), Ying Huang (Author), Guilan Quan (Author), Chune Zhu (Author), Xing Li (Author), Xin Pan (Author), Chuanbin Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to develop a novel anhydrous reverse micelle nanoparticles (ARM-NPs) system to overcome the sedimentation instability of peptide-containing pressurized metered-dose inhalers (pMDIs). A bottom-up method was utilized to fabricate ARM-NPs. Tertiary butyl alcohol (TBA)/wa...