Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass

• 主要な著者: Rebecca J. Wilson (著者), Scott P. Lyons (著者), Timothy R. Koves (著者), Victoria G. Bryson (著者), Hengtao Zhang (著者), TianYu Li (著者), Scott B. Crown (著者), Jin-Dong Ding (著者), Paul A. Grimsrud (著者), Paul B. Rosenberg (著者), Deborah M. Muoio (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is known to be indispensable during development...