Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass

• Main Authors: Rebecca J. Wilson (Author), Scott P. Lyons (Author), Timothy R. Koves (Author), Victoria G. Bryson (Author), Hengtao Zhang (Author), TianYu Li (Author), Scott B. Crown (Author), Jin-Dong Ding (Author), Paul A. Grimsrud (Author), Paul B. Rosenberg (Author), Deborah M. Muoio (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is known to be indispensable during development...