Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice

• Main Authors: Feng Huang (Author), Na Na (Author), Takeshi Ijichi (Author), Xiaokang Wu (Author), Kazutaka Miyamoto (Author), Alessandra Ciullo (Author), My Tran (Author), Liang Li (Author), Ahmed Ibrahim (Author), Eduardo Marbán (Author), Geoffrey de Couto (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiosphere-derived cell exosomes (CDCexo) and YF1, a CDCexo-derived non-coding RNA, elicit therapeutic bioactivity in models of myocardial infarction and hypertensive hypertrophy. Here we tested the hypothesis that YF1, a 56-nucleotide Y RNA fragment, could alleviate cardiomyocyte hypertrophy, inf...