Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists

• Main Authors: Mohiuddin Ahmed Bhuiyan (Author), Murad Hossain (Author), Masaji Ishiguro (Author), Takashi Nakamura (Author), Takafumi Nagatomo (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis. We also compared our results with the wild-type AT1 receptor and investigated...