In Vivo Safety and Efficacy of Chalcone-Loaded Microparticles with Modified Polymeric Matrix against Cutaneous Leishmaniasis

• Main Authors: Ariane de J. Sousa-Batista (Author), Natalia Arruda-Costa (Author), Wallace Pacienza-Lima (Author), Felipe Carvalho-Gondim (Author), Rosiane F. Santos (Author), Silvia A. G. Da-Silva (Author), Maria Inês Ré (Author), Bartira Rossi-Bergmann (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current chemotherapy of cutaneous leishmaniasis (CL) is based on repeated systemic or intralesional administration of drugs that often cause severe toxicity. Previously, we demonstrated the therapeutic potential of biodegradable poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) loaded with 8...