Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

• Main Authors: Daniel A. S. Kitagawa (Author), Rafael B. Rodrigues (Author), Thiago N. Silva (Author), Wellington V. dos Santos (Author), Vinicius C. V. da Rocha (Author), Joyce S. F. D. de Almeida (Author), Leandro B. Bernardo (Author), Taynara Carvalho-Silva (Author), Cintia N. Ferreira (Author), Angelo A. T. da Silva (Author), Alessandro B. C. Simas (Author), Eugenie Nepovimova (Author), Kamil Kuča (Author), Tanos C. C. França (Author), Samir F. de A. Cavalcante (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a broad spectrum, are not effective towards all organop...