Pharmacokinetics and Toxicity Evaluation of a PLGA and Chitosan-Based Micro-Implant for Sustained Release of Methotrexate in Rabbit Vitreous

• Main Authors: Soumyarwit Manna (Author), Anna M. Donnell (Author), Rafaela Q. Caixeta Faraj (Author), Blanca I. Riemann (Author), Christopher D. Riemann (Author), James J. Augsburger (Author), Zelia M. Correa (Author), Rupak K. Banerjee (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present research investigates the pharmacokinetics and toxicity of a chitosan (CS) and poly(lactic-co-glycolic) acid (PLGA)-based methotrexate (MTX) intravitreal micro-implant in normal rabbit eyes. PLGA and CS-based micro-implants containing 400 µg of MTX were surgically inserted in the vitreou...