Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model

• Main Authors: Zachary D. C. Burke (Author), Christopher M. Hart (Author), Benjamin V. Kelley (Author), Zeinab Mamouei (Author), Gideon W. Blumstein (Author), Christopher Hamad (Author), Kellyn Hori (Author), Nicolas Cevallos (Author), Christina Villalpando (Author), Nicole Truong (Author), Amr Turkmani (Author), Micah Ralston (Author), Aaron Kavanaugh (Author), Edgar Tenorio (Author), Lawrence M. Kauvar (Author), Alan Li (Author), Nathanael Prunet (Author), Alexandra I. Stavrakis (Author), Nicholas M. Bernthal (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bacterial biofilms on orthopedic implants are resistant to the host immune response and to traditional systemic antibiotics. Novel therapies are needed to improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against a biofilm anchoring protein. For assessment of this agent in an or...