Synthesis and structure-activity relationships for some novel diflapolin derivatives with benzimidazole subunit

• Main Authors: Lisa Vieider (Author), Eva Zoeller (Author), Erik Romp (Author), Martin Schoenthaler (Author), Victor Hernández-Olmos (Author), Veronika Temml (Author), Thomas Hasenoehrl (Author), Daniela Schuster (Author), Oliver Werz (Author), Ulrike Garscha (Author), Barbara Matuszczak (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesised, and characterised. These novel compounds, which contain a benzimidazole subunit were evaluated for their inhibitory activity against sEH...