A Hypothesis Concerning the Biphasic Dose-response of Tumors to Angiostatin and Endostatin
This manuscript proposes a hypothesis to explain the U-shaped dose-response observed for angiostatin and other high-molecular-weight drugs in various anti-cancer bio-assays. The dose-response curves for angiostatin and endostatin (measured as suppression of tumor growth) go through an optimum (i.e.,...
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SAGE Publishing,
2015-05-01T00:00:00Z.
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