Gemini Cationic Lipid-Type Nanovectors Suitable for the Transfection of Therapeutic Plasmid DNA Encoding for Pro-Inflammatory Cytokine Interleukin-12

• Main Authors: Natalia Sánchez-Arribas (Author), María Martínez-Negro (Author), Clara Aicart-Ramos (Author), Conchita Tros de Ilarduya (Author), Emilio Aicart (Author), Andrés Guerrero-Martínez (Author), Elena Junquera (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ample evidence exists on the role of interleukin-12 (IL-12) in the response against many pathogens, as well as on its remarkable antitumor properties. However, the unexpected toxicity and disappointing results in some clinical trials are prompting the design of new strategies and/or vectors for IL-1...