Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy

• Main Authors: Raphael Mietzner (Author), Christian Kade (Author), Franziska Froemel (Author), Diana Pauly (Author), W. Daniel Stamer (Author), Andreas Ohlmann (Author), Joachim Wegener (Author), Rudolf Fuchshofer (Author), Miriam Breunig (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rho-associated protein kinase (ROCK) inhibitors allow for causative glaucoma therapy. Unfortunately, topically applied ROCK inhibitors suffer from high incidence of hyperemia and low intraocular bioavailability. Therefore, we propose the use of poly (lactide-co-glycolide) (PLGA) microspheres as a de...