Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery

• Main Authors: Wenyi Song (Author), Yuting Yang (Author), Miaorong Yu (Author), Quanlei Zhu (Author), Mohammadali Soleimani Damaneh (Author), Haijun Zhong (Author), Yong Gan (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Self-nanoemulsifying systems (SNEs) have excellent ability to improve the solubility of poorly water-soluble drugs (PWSD). However, SNEs are likely to be degraded in gastrointestinal (GIT) when their surface is recognized by lipase/co-lipase enzyme complex, resulting in rapid release and precipitati...