Development and characterization of an atorvastatin solid dispersion formulation using skimmed milk for improved oral bioavailability

• Main Authors: Ankush Choudhary (Author), Avtar C. Rana (Author), Geeta Aggarwal (Author), Virender Kumar (Author), Foziyah Zakir (Author)
• Format: Book
• Published: Elsevier, 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atorvastatin has low aqueous solubility resulting in low oral bioavailability (12%) and thus presents a challenge in formulating a suitable dosage form. To improve the aqueous solubility, a solid dispersion formulation of atorvastatin was prepared by lyophilization utilising skimmed milk as a carrie...