Tanshinone IIA Suppresses Proliferation and Inflammatory Cytokine Production of Synovial Fibroblasts from Rheumatoid Arthritis Patients Induced by TNF-α and Attenuates the Inflammatory Response in AIA Mice

• Main Authors: Hongyan Du (Author), Yuechun Wang (Author), Yongchang Zeng (Author), Xiaoming Huang (Author), Dingfei Liu (Author), Lvlan Ye (Author), Yang Li (Author), Xiaochen Chen (Author), Tiancai Liu (Author), Hongwei Li (Author), Jing Wu (Author), Qinghong Yu (Author), Yingsong Wu (Author), Ligang Jie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease in which activated RA fibroblast-1ike synoviocytes (RA-FLSs) are one of the main factors responsible for inducing morbidity. Previous reports have shown that RA-FLSs have proliferative features similar to cancer cells, in addi...