Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation

• Main Authors: David A. Davis (Author), Haydar Bulut (Author), Prabha Shrestha (Author), Hiroaki Mitsuya (Author), Robert Yarchoan (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Most viruses encode their own proteases to carry out viral maturation and these often require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2) and human T-cell leukemia virus (HTLV-1) proteases have shown that the activity of these proteases can be re...