Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study

• Main Authors: Luiz Henrique Guerreiro (Author), Daniel da Silva (Author), Wendell Girard-Dias (Author), Camile Moreira Mascarenhas (Author), Kildare Miranda (Author), Mauro Sola-Penna (Author), Eduardo Ricci Júnior (Author), Luís Mauricio Trambaioli da Rocha e Lima (Author)
• Format: Book
• Published: Universidade de São Paulo, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (P...