Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis

• Main Authors: Chan-Yen Kuo (Author), Valeria Chiu (Author), Po-Chun Hsieh (Author), Chun-Yen Huang (Author), S. Joseph Huang (Author), I-Shiang Tzeng (Author), Fu-Ming Tsai (Author), Mao-Liang Chen (Author), Chien-Ting Liu (Author), Yi-Ru Chen (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatitis B virus X protein (HBx) and hepatic stellate cells (HSCs) are critical for liver fibrosis development. Anti-fibrosis occurs via reversion to quiescent-type HSCs or clearance of HSCs via apoptosis or ferroptosis. We aimed to elucidate the role of chrysophanol in rat HSC-T6 cells expressing...