The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR.

• Main Authors: Jo-Chi Kao (Author), Wei-Chun HuangFu (Author), Tsung-Ting Tsai (Author), Min-Ru Ho (Author), Ming-Kai Jhan (Author), Ting-Jing Shen (Author), Po-Chun Tseng (Author), Yung-Ting Wang (Author), Chiou-Feng Lin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo. PRINCIPLE FINDING:Niclosamide effectively retarded DENV-i...