The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR.

• Главные авторы: Jo-Chi Kao (Автор), Wei-Chun HuangFu (Автор), Tsung-Ting Tsai (Автор), Min-Ru Ho (Автор), Ming-Kai Jhan (Автор), Ting-Jing Shen (Автор), Po-Chun Tseng (Автор), Yung-Ting Wang (Автор), Chiou-Feng Lin (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2018-08-01T00:00:00Z.
• Предметы: article
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BACKGROUND:The antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo. PRINCIPLE FINDING:Niclosamide effectively retarded DENV-i...