Time‐dependent clearance can confound exposure-response analysis of therapeutic antibodies: A comprehensive review of the current literature
Abstract Exposure-response (ER) analysis is used to optimize dose and dose regimens during clinical development. Characterization of relationships between drug exposure and efficacy or safety outcomes can be utilized to make dose adjustments that improve patient response. Therapeutic antibodies typi...
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Wiley,
2024-01-01T00:00:00Z.
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A1234.567 |
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