Oxidized-LDL Deteriorated the Renal Residual Function and Parenchyma in CKD Rat through Upregulating Epithelial Mesenchymal Transition and Extracellular Matrix-Mediated Tubulointerstitial Fibrosis-Pharmacomodulation of Rosuvastatin

• Автори: Pei-Hsun Sung (Автор), Ben-Chung Cheng (Автор), Tsuen-Wei Hsu (Автор), John Y Chiang (Автор), Hsin-Ju Chiang (Автор), Yi-Ling Chen (Автор), Chih-Chao Yang (Автор), Hon-Kan Yip (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

This study tested the hypothesis that intrarenal arterial transfusion of oxidized low-density lipoprotein (ox-LDL) jeopardized the residual renal function and kidney architecture in rat chronic kidney disease ((CKD), i.e., induced by 5/6 nephrectomy) that was reversed by rosuvastatin. Cell culture w...