Impact of Vancomycin‐Induced Changes in the Intestinal Microbiota on the Pharmacokinetics of Simvastatin

• Main Authors: Jung Sunwoo (Author), Sang Chun Ji (Author), Andrew HyoungJin Kim (Author), Kyung‐Sang Yu (Author), Joo‐Youn Cho (Author), In‐Jin Jang (Author), SeungHwan Lee (Author)
• Format: Book
• Published: Wiley, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetic (PK) properties of drugs are affected in several ways by interactions with microbiota. The aim of this study was to investigate the effects of oral vancomycin on the gut microbiota and, consequently, on the PKs of simvastatin. An open‐label, single arm, sequential crossover study...