Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery

• Main Authors: Mohamed Kreir (Author), Dea Putri (Author), Fetene Tekle (Author), Francesca Pibiri (Author), Constantin d'Ydewalle (Author), Karel Van Ammel (Author), Helena Geys (Author), Ard Teisman (Author), David J. Gallacher (Author), Hua Rong Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of positive and negative controls, as well as data from...