Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery

• मुख्य लेखकों: Mohamed Kreir (लेखक), Dea Putri (लेखक), Fetene Tekle (लेखक), Francesca Pibiri (लेखक), Constantin d'Ydewalle (लेखक), Karel Van Ammel (लेखक), Helena Geys (लेखक), Ard Teisman (लेखक), David J. Gallacher (लेखक), Hua Rong Lu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of positive and negative controls, as well as data from...