Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation. In this study, we examined whether cGAS plays a rol...

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Main Authors: Yan Wang (Author), Guo-Hua Su (Author), Fang Zhang (Author), Jing-Xue Chu (Author), Yun-Shan Wang (Author)
Format: Book
Published: Hindawi Limited, 2015-01-01T00:00:00Z.
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