Design, Synthesis, and Evaluation of Benzoheterocyclic-Containing Derivatives as Novel HDAC1 Inhibitors

Abstract In this study, the synthesis and biological evaluation of a variety of benzoheterocyclic-containing benzamide derivatives were described. Some of these compounds were proved to inhibiting the activity of histone deacetylase 1 (HDAC1) with IC50 values below the micromolar range, retarding pr...

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Main Authors: Min-Ru Jiao (Author), Bo Han (Author), Xiu Gu (Author), Hao Zhang (Author), Ai-Ping Wang (Author), Qing-Wei Zhang (Author)
Format: Book
Published: Georg Thieme Verlag KG, 2022-03-01T00:00:00Z.
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