Rapid and sensitive analysis of cyclobenzaprine by LC-MS/MS: Application to a pharmacokinetic study of cyclobenzaprine in dog

• Main Authors: Wenhong Yu (Author), Xiaojing Yang (Author), Wenwen Sui (Author), Haiyan Xu (Author), Xinyi Luan (Author), Xiangjun Wang (Author), Yi Jin (Author), Bo Yuan (Author)
• Format: Book
• Published: Elsevier, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rapid and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of cyclobenzaprine in dog plasma. After extracted with organic solvent, post-treatment samples were separated on an Agela C18 column interfaced with a triple quadrupole tand...