Molecular Docking, ADMET Study, Synthesis, Characterization and Preliminary Antiproliferative Activity of Potential Histone Deacetylase Inhibitors with Isoxazole as New Zinc Binding Group
Histone acetylation is a highly interesting epigenetic target for drug therapy. Histone deacetylase enzymes (HDACs) are overexpressed in several diseases, including cancers. Most of the clinically used HDAC inhibitors involve hydroxamate group as a zinc-binding group (ZBG). Hydroxamates have a poor...
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| Main Authors: | , |
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| Format: | Book |
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College of Pharmacy University of Baghdad,
2023-11-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |