Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity

• Main Authors: Yiyuan Chen (Author), Jonathan G. Moloney (Author), Kirsten E. Christensen (Author), Mark G. Moloney (Author)
• Format: Book
• Published: MDPI AG, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a h...