Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4^CRBN Protein Degradation Axis

• Main Authors: Seung-Joo Yang (Author), Seungje Jeon (Author), Jeong Won Baek (Author), Kwang Min Lee (Author), Chul-Seung Park (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4^CRBN) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4^CRBN E3 ubiquitin ligase...