A mechanistic PK/PD model of AZD0171 (anti‐LIF) to support Phase II dose selection

A mechanistic PK/PD model of AZD0171 (anti‐LIF) to support Phase II dose selection

Abstract AZD0171 (INN: Falbikitug) is being developed as a humanized monoclonal antibody (mAb), immunoglobulin G subclass 1 (IgG1), which binds specifically to the immunosuppressive human cytokine leukemia inhibitory factor (LIF) and inhibits downstream signaling by blocking recruitment of glycoprot...

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Main Authors: Azar Shahraz (Author), Mark Penney (Author), Juliana Candido (Author), Grace Opoku‐Ansah (Author), Melanie Neubauer (Author), Jim Eyles (Author), Oluwaseun Ojo (Author), Nelson Liu (Author), Nadia M. Luheshi (Author), Alex Phipps (Author), Karthick Vishwanathan (Author)
Format: Book
Published: Wiley, 2024-10-01T00:00:00Z.
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