FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve

• Main Authors: Julia Rehnitz (Author), Diego D. Alcoba (Author), Ilma S. Brum (Author), Jens E. Dietrich (Author), Berthe Youness (Author), Katrin Hinderhofer (Author), Birgitta Messmer (Author), Alexander Freis (Author), Thomas Strowitzki (Author), Ariane Germeyer (Author)
• Format: Book
• Published: BMC, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fragile-X-Mental-Retardation-1- (FMR1)-gene is supposed to be a key gene for ovarian reserve and folliculogenesis. It contains in its 5'-UTR a triplet-base-repeat (CGG), that varies between 26 and 34 in general population. CGG-repeat-lengths with 55-200 repeats (pre-mutation...