New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein

• Main Authors: Ryan R. Myers (Author), Jonatan Sanchez-Garcia (Author), Daniel C. Leving (Author), Richard G. Melvin (Author), Pedro Fernandez-Funez (Author)
• Format: Book
• Published: The Company of Biologists, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Misfolding of the prion protein (PrP) is responsible for devastating neurological disorders in humans and other mammals. An unresolved problem in the field is unraveling the mechanisms governing PrP conformational dynamics, misfolding, and the cellular mechanism leading to neurodegeneration. The var...