Design, synthesis and biological evaluation of novel triazoloquinazolinone and imidazoquinazolinone derivatives as allosteric inhibitors of SHP2 phosphatase

• Main Authors: Wenjun Ye (Author), Ye Liu (Author), Qian Ren (Author), Tianhui Liao (Author), Yumei Chen (Author), Dongmei Chen (Author), Sisi Wang (Author), Lihong Yao (Author), Yihe Jia (Author), Chunshen Zhao (Author), Zhixu Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel triazoloquinolinone and imidazoquinazolinone derivatives were designed and synthesised, and their biological activities against SHP2 protein and melanoma A357 cell line were evaluated in vitro. The results show that some target compounds have moderate to excellent inhibitory activi...