Structures, substrates, and regulators of mammalian Sirtuins - opportunities and challenges for drug development

• Main Authors: Sebastien eMoniot (Author), Michael eWeyand (Author), Clemens eSteegborn (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1-7, which differ in their substrate specificities and subcellular localizations. The physiological functions of Sirtuins make them interesting the...