BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection

• Main Authors: Yue Chen (Author), Xin Yi (Author), Bo Huo (Author), Yi He (Author), Xian Guo (Author), Zihao Zhang (Author), Xiaoxuan Zhong (Author), Xin Feng (Author), Ze-Min Fang (Author), Xue-Hai Zhu (Author), Xiang Wei (Author), Ding-Sheng Jiang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the excessive lipid peroxidation accumulation. However, whether targeting ferroptosis is an effective approach for SMC l...