Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

• Main Authors: Ittipat Meewan (Author), Jacob Kattoula (Author), Julius Y. Kattoula (Author), Danielle Skinner (Author), Pavla Fajtová (Author), Miriam A. Giardini (Author), Brendon Woodworth (Author), James H. McKerrow (Author), Jair Lage de Siqueira-Neto (Author), Anthony J. O'Donoghue (Author), Ruben Abagyan (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against <i>three</i> key proteases involved in SARS-CoV-...