Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis

• Main Authors: Abhijeet Dhiman (Author), Chanchal Kumar (Author), Subodh Kumar Mishra (Author), Kriti Sikri (Author), Ishara Datta (Author), Pradeep Sharma (Author), Tej P. Singh (Author), Sagarika Haldar (Author), Neera Sharma (Author), Anjali Bansal (Author), Yusra Ahmad (Author), Amit Kumar (Author), Tarun Kumar Sharma (Author), Jaya Sivaswami Tyagi (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The successful management of tuberculosis (TB) requires efficient diagnosis and treatment. Further, the increasing prevalence of drug-resistant TB highlights the urgent need to develop novel inhibitors against both drug-susceptible and drug-resistant forms of disease. Malate synthase (MS), an enzyme...